Pulmonary manifestations of the idiopathic inflammatory myopathies in a South African population

Main Article Content

T Hes
M Wong
M Tikly
N Govind

Abstract





Background. Pulmonary complications cause significant morbidity and mortality in patients with idiopathic inflammatory myopathies (IIMs).


Objectives. To describe the frequency and spectrum of pulmonary complications in patients with IIMs in South Africa (SA).


Methods. A retrospective records review of adult patients with IIMs or clinically amyopathic dermatomyositis (CADM) presenting with respiratory complaints at a tertiary care facility in SA was performed. Clinical features, results of laboratory and pulmonary function tests (PFTs), radiological findings and treatment were recorded.


Results. Pulmonary complications were documented in 66 patients. Most patients (n=41; 62.1%) had dermatomyositis, 14 (21.2%) had polymyositis, and 3 (4.5%) had CADM. There were 8 patients with overlap syndromes. Dyspnoea and a dry cough were the most common presenting symptoms, in 52 (78.8%) and 36 (54.5%) patients, respectively. Bibasal crackles were noted in 38 patients (57.6%). Interstitial lung disease (ILD), followed by infection and pulmonary hypertension (PH), were documented in 46 (69.7%), 16 (24.2%) and 9 (13.6%) patients, respectively. Nine patients had microbiologically confirmed pulmonary tuberculosis. Patients who were anti-Jo1 antibody positive (n=16) had higher levels of acute inflammatory markers and muscle enzymes compared with the rest of the patients (p<0.0001). Dyspnoea and bibasal crackles were associated with significantly lower baseline and 12-month lung function parameters. Nonspecific interstitial pneumonia was the most common radiological pattern of ILD, present in 25 (62.5%) of the patients with ILD.


Conclusion. ILD was the most prevalent complication in this study of SA patients with IIMs. Pulmonary infections and PH were also significant contributors to morbidity. The presence of dyspnoea and crackles was predictive of lower baseline PFTs in this population.





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How to Cite
1.
Hes T, Wong M, Tikly M, Govind N. Pulmonary manifestations of the idiopathic inflammatory myopathies in a South African population. Afr J Thoracic Crit Care Med [Internet]. 2024 Oct. 14 [cited 2024 Nov. 6];30(3):e1663. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/1663
Section
Original Research: Articles
Author Biographies

M Wong, Department of Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Head Division of Pulmonology, Department of Medicine, Chris Hani Baragwanath Academic Hospital

M Tikly, Department of Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Division of Rheumatology, Department of Medicine, Chris Hani Baragwanath Academic Hospital

N Govind, Department of Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Division of Rheumatology, Department of Medicine, Chris Hani Baragwanath Academic Hospital 

How to Cite

1.
Hes T, Wong M, Tikly M, Govind N. Pulmonary manifestations of the idiopathic inflammatory myopathies in a South African population. Afr J Thoracic Crit Care Med [Internet]. 2024 Oct. 14 [cited 2024 Nov. 6];30(3):e1663. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/1663

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