Cases Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia
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Abstract
Methotrexate, an immunomodulatory agent used for a wide variety of indications, can cause pulmonary toxicity in the form of pneumonitis, organising pneumonia, pulmonary fibrosis, pleural effusion, pulmonary infections or lymphoproliferative disease. We report a case of methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. The diagnosis of methotrexate pneumonitis is challenging, as the signs and symptoms can be caused by intercurrent infection, concomitant medications or an underlying disease condition. A high index of suspicion is required for diagnosis. Management consists of drug discontinuation and steroids in patients with respiratory failure.
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References
Jakubovic BD, Donovan A, Webster PM, Shear NH. Methotrexate-induced pulmonary toxicity. Can Respir J 2013;20(3):153-155. https://doi. org/10.1155/2013/527912
Chhabra P, Law AD, Suri V, Malhotra P, Varma S. Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report. Mediterr J Hematol Infect Dis 2012;4(1):e2012020. https://doi. org/10.4084/MJHID.2012.020
Salehi M, Miller R, Khaing M. Methotrexate-induced hypersensitivity pneumonitis appearing after 30 years of use: A case report. J Med Case Rep 2017;11(1):174. https://doi.org/10.1186/s13256-017-1333-0
Imokawa S, Colby TV, Leslie KO, Helmers RA. Methotrexate pneumonitis: Review of the literature and histopathological findings in nine patients. Eur Respir J 2000;15(2):373-381. https://doi.org/10.1034/ j.1399-3003.2000.15b25.x
SearlesG,McKendryRJ.Methotrexatepneumonitisin rheumatoid arthritis: Potential risk factors. Four case reports and a review of the literature. J Rheumatol 1987;14(6):1164-1171.
Barrera P, Laan RFJM, van Reil PLCM, Dekhuijen PNR, Boerbooms AMTh, van de Putte LBA. Methotrexate related pulmonary complications in rheumatoid arthritis. Ann Rheum Dis 1994;53(7):434- 439. https://doi.org/10.1136/ard.53.7.434
Gillespie AM, Lorigan PC, Radstone CR, Waterhouse JC, Coleman RE, Hancock BW. Pulmonary function in patients with trophoblastic disease treated with low-dose methotrexate. Br J Cancer 1997;76(10):1382- 1386. https://doi.org/10.1038/bjc.1997.564
Zhang D, Ding Z, Qian J, Xie X, Wang Y. Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. Eur J Gynaecol Oncol 2008;29(4):390-392.