Cases Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia

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M Agarwal
K K Sharma
K Deokar
N Bharti

Abstract





Methotrexate, an immunomodulatory agent used for a wide variety of indications, can cause pulmonary toxicity in the form of pneumonitis, organising pneumonia, pulmonary fibrosis, pleural effusion, pulmonary infections or lymphoproliferative disease. We report a case of methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. The diagnosis of methotrexate pneumonitis is challenging, as the signs and symptoms can be caused by intercurrent infection, concomitant medications or an underlying disease condition. A high index of suspicion is required for diagnosis. Management consists of drug discontinuation and steroids in patients with respiratory failure.





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How to Cite
1.
Agarwal M, Sharma KK, Deokar K, Bharti N. Cases: Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. Afr J Thoracic Crit Care Med [Internet]. 2022 Oct. 4 [cited 2024 Dec. 1];28(3):133-4. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/249
Section
Correspondence: Case Reports

How to Cite

1.
Agarwal M, Sharma KK, Deokar K, Bharti N. Cases: Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. Afr J Thoracic Crit Care Med [Internet]. 2022 Oct. 4 [cited 2024 Dec. 1];28(3):133-4. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/249

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