A review of the role of testosterone in the care of the critically ill patient

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R Stevenson
D Bishop
R Rodseth


Testosterone is an anabolic and androgenic steroid hormone therapeutically used to produce male sex characteristics. It has also been shown to have a modulating effect on proinflammatory biomarkers. Critical illness is characterised by a proinflammatory and catabolic state and is accompanied by altered testosterone production, which may persist into the recovery phase. Testosterone may, therefore be a potential therapeutic option in critical illness. This paper reviews normal testosterone physiology, and the changes seen during critical illness and systematically reviews testosterone therapy during both the acute and chronic phases of critical illness.

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A review of the role of testosterone in the care of the critically ill patient. (2024). Southern African Journal of Critical Care, 40(1). https://doi.org/10.7196/SAJCC.2024.v40i1.1303
Review Articles
Author Biographies

D Bishop, Department of Anaesthesia and Critical Care, University of KwaZulu-Natal, Pietermaritzburg, South Africa

Honorary Associate Professor, Department of Anaesthesia and Critical Care, University of KwaZulu-Natal, Pietermaritzburg, South Africa

R Rodseth, Department of Anaesthesia and Critical Care, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Netcare Ltd, Johannesburg, South Africa

Honorary Associate Professor, Department of Anaesthesia and Critical Care, University of KwaZulu-Natal, Pietermaritzburg, South Africa

How to Cite

A review of the role of testosterone in the care of the critically ill patient. (2024). Southern African Journal of Critical Care, 40(1). https://doi.org/10.7196/SAJCC.2024.v40i1.1303


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