Forthcoming Issue Vol. 19 no. 1 Clinical, laboratory and echocardiographic parameters suggestive of Multi-system Inflammatory Syndrome in Children (MIS-C) at a tertiary hospital in South Africa

Main Article Content

V Mammen
A Alharm
T David
M Monareng
P Raphulu
W Sethomo
K Thandrayen
A Cilliers

Abstract

Background: Worldwide studies have described features and outcomes of Multi-system Inflammatory Syndrome in Children (MIS-C) to assist with the diagnosis and guide medical management, with few studies emanating from Africa.


Methods: The paediatric cardiology database identified all patients referred with suspected MIS-C at a large tertiary hospital in South Africa, from 1st March 2020 till 31st December 2021. Patients were classified into “MIS-C likely” or “MIS-C unlikely” based on the 2020 CDC criteria for MIS-C.


Results: 101 patients were analysed, with 60 in the “MIS-C likely” group and 41 patients in the “MIS-C unlikely” group. The significant clinical features differentiating between “MIS-C likely” and the “MIS-C unlikely” group was the presence of documented fever (p=0.018) and eye changes (p< 0.001). Patients that had a Covid antibody test that was positive and were referred for suspected MIS-C were most likely to present with MIS-C (p< 0.001). Laboratory parameters suggesting a greater likelihood of patients having MIS-C was a high Troponin T (p=0.018) and a high CRP (p=0.019). The main echocardiographic feature associated with a MIS-C diagnosis is LV dysfunction at presentation (p=0.023).


Conclusions: Clinical features such as documented fever and eye changes together with a positive Covid antibody test suggest that patients had MIS-C in our setting. Laboratory findings of CRP and Troponin T in patients with suspected MIS-C assisted with the diagnosis. Patients with suspected MIS-C with LV dysfunction at presentation were more likely to have MIS-C.

Article Details

How to Cite
Forthcoming Issue Vol. 19 no. 1: Clinical, laboratory and echocardiographic parameters suggestive of Multi-system Inflammatory Syndrome in Children (MIS-C) at a tertiary hospital in South Africa. (2024). South African Journal of Child Health. https://doi.org/10.7196/
Section
Research

How to Cite

Forthcoming Issue Vol. 19 no. 1: Clinical, laboratory and echocardiographic parameters suggestive of Multi-system Inflammatory Syndrome in Children (MIS-C) at a tertiary hospital in South Africa. (2024). South African Journal of Child Health. https://doi.org/10.7196/

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