Forthcoming Issue Vol. 19 no. 1 Combination of Aripiprazole and Valproate in Children with Tic Disorders: Case Series
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Abstract
Tic is a disorder characterized by involuntary, repetitive movements and vocalizations that significantly impair affected children's quality of life. These disorders, primarily originating in the basal ganglia, are often misdiagnosed and inadequately treated. The exact etiology of tic disorders is believed to involve a combination of genetic, neurobiological, and environmental factors. Stress is an exacerbating factor leading to an increase in tic frequency and intensity.
This report presented three cases of children diagnosed with tic disorders who exhibited substantial improvement through a combination of Aripiprazole and Valproate. The children, aged 7 to 15 years old, had previously received various treatments with limited success. Upon switching to the combined therapy of Aripiprazole and Valproate, they showed marked improvement in tic severity and associated behavioral issues. The combination treatment underscores the need for further research to validate these observations and to refine treatment protocols for pediatrics with tic disorders.
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