An audit of infants presenting with cholestatic jaundice at a secondary hospital in Johannesburg, South Africa

Main Article Content

N Yachad
T De Maayer

Abstract





Background. Neonatal cholestatic jaundice is a common paediatric condition with a paucity of recent local data and a notable absence of locally influenced diagnostic algorithms.


Objectives. To describe the causes of cholestatic jaundice, investigations conducted and patient outcomes.


Methods. This was a retrospective file review of 96 patients presenting to the Specialist Clinic at Rahima Moosa Mother and Child Hospital in Johannesburg between 1 January 2014 and 31 December 2020. Clinical features, serum biochemistry at presentation, diagnostic investigations (haematological, radiological and histological), diagnosis and outcome were analysed during data collection.


Results. Ninety-six patients were included in the study. The median age of jaundice onset was at 2 months, while the median age of presentation was 3.3 months. Causes of jaundice fell into three main categories: 38 had biliary atresia (BA); 24 had another specific diagnosis; and 34 remained without an underlying diagnosis (idiopathic neonatal hepatitis). An overall mortality rate of 26% was noted at a median (interquartile range) age of 13 (5 - 24) months and it was highest in the BA group (n=14; 56%).


Conclusion. The evaluation of neonatal jaundice requires a wide differential and expeditious referral to optimise outcomes and avoid complications. Many patients remained undiagnosed, and the overall prognosis was poor. The authors recommend the development of a locally relevant diagnostic protocol to minimise delays in the identification, diagnosis and treatment of neonatal jaundice.





Article Details

How to Cite
An audit of infants presenting with cholestatic jaundice at a secondary hospital in Johannesburg, South Africa. (2024). South African Journal of Child Health, 18(2), e881. https://doi.org/10.7196/SAJCH.2024.v18i2.881
Section
Research

How to Cite

An audit of infants presenting with cholestatic jaundice at a secondary hospital in Johannesburg, South Africa. (2024). South African Journal of Child Health, 18(2), e881. https://doi.org/10.7196/SAJCH.2024.v18i2.881

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