The changing landscape of antimicrobial resistance and use in South Africa: The need for access to new antibiotics: A position paper

Authors

  • H Finlayson Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
  • V Chibabhai Division of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • P Jeena Department of Paediatrics and Child Health, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
  • S Kolman Nelson Mandela Children’s Hospital, Johannesburg, South Africa
  • W Lowman PathCare/Vermaak Pathologists, Gauteng; Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa
  • T C Manzini Infectious Disease Unit, Sefako Makgatho Health Science University and Dr George Mukhari Academic Hospital, Pretoria, South Africa
  • T Nana Division of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • J Nuttall Paediatric Infectious Diseases Unit, Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa
  • A Parker Unit for Infection Prevention Control and Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
  • P Skosana Department of Clinical Pharmacy, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa
  • V Ueckermann Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of Pretoria, South Africa
  • A Wise Rahima Moosa Mother and Child Hospital, Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

DOI:

https://doi.org/10.7196/SAMJ.2024.v114i10.2348

Keywords:

antimicrobial resistance, antimicrobial use, antibiotic stewardship, AwaRE antibiotics

Abstract

Antibiotic resistance is a global threat, with a disproportionate burden of mortality in low- and middle-income countries. It is increasing in both the public and private healthcare sectors within South Africa, especially in Gram-negative organisms, and is associated with increased use of World Health Organization watch and reserve antibiotics. There is a need for improved access to new antibiotics to treat infections caused by drug-resistant organisms in order to limit side-effects and improve patient outcomes of currently available antibiotics. We propose the responsible introduction of these new antibiotics with both administrative and clinical oversight in order to preserve the longevity of these precious antibiotics.

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Published

2024-10-03

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How to Cite

1.
Finlayson H, Chibabhai V, Jeena P, Kolman S, Lowman W, Manzini TC, et al. The changing landscape of antimicrobial resistance and use in South Africa: The need for access to new antibiotics: A position paper. S Afr Med J [Internet]. 2024 Oct. 3 [cited 2025 Apr. 30];114(10):e2348. Available from: https://samajournals.co.za/index.php/samj/article/view/2348

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