Paediatric gastrointestinal endoscopy: Experience in Red Cross War Memorial Children’s Hospital, Cape Town, South Africa
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Abstract
Background. Endoscopy is an important diagnostic and therapeutic mode of management in children with gastrointestinal disorders.
Objective. To determine the indications, endoscopic yields and impact of the service on the ongoing health and complications among children who underwent gastrointestinal endoscopy at Red Cross War Memorial Children’s Hospital, Cape Town.
Methods. A 10-year (2007 - 2016) retrospective study of children <18 years old who underwent gastrointestinal endoscopy was undertaken using relevant patients’ variables obtained from their hospital medical records. Data were analysed using Stata 13.1 (p<0.05).
Results. A total of 402 children underwent a total of 695 gastrointestinal endoscopic procedures: 592 (85.2%) were gastroscopies, 78 (11.2%) combined gastroscopies with colonoscopies and 25 (3.6%) colonoscopy-only procedures, respectively. The main diagnostic indications for gastroscopy, gastroscopy combined with colonoscopy and colonoscopy-only were chronic abdominal pain (n=49; 12.2%), suspected inflammatory bowel disease (n=30; 7.5%) and rectal bleeding (n=13; 52.0%) respectively. The most common therapeutic indication for gastroscopy was change of a percutaneous endoscopic gastrostomy (n=143; 35.6%) while for colonoscopy 6 (5.8%) had polypectomy. Abnormal histopathological results were made from both macroscopically normal- and abnormal-looking tissues, though with no statistically significant relationship.
Conclusion. Endoscopy offers diagnostic and therapeutic options in children. Positive histological findings were obtained in some cases where gastrointestinal mucosae appeared normal. There is need to obtain biopsies from both macroscopically normal- and abnormallooking gastrointestinal mucosae as positive histological findings could be made from them and hence improve diagnostic yield.
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References
Tringali A, Thomson N, Dumonceau JM, et al. Pediatric gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition Guideline Executive Summary. Endoscopy 2017;49(1):83-91. https://doi.org/10.1055/s-0042-111002
Wang S, Younas O, Rawat D, et al. Clinical presentation and outcomes of
diagnostic endoscopy in newly presenting children with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr 2018; 66(6):876-81. https://doi.
org/10.1097/mpg.0000000000001864
Nel ED. A brief review of the history of paediatric gastroenterology. S Afr Gastroenterol Rev 2013;11(2):16-18.
Belsha D, Bremner R, Thomson M. Indications for gastrointestinal endoscopy in childhood. Arch Dis Child 2016;101(12):1-8. https://doi.org/10.1136/archdischild-2014-306043.
Friedt M, Welsch S. An update on paediatric endoscopy. Eur J Med Res 2013;18(1):24. https://doi.org/10.1186/2047-783x-18-24
Rubio-Tapai A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG Clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol 2013;108(5): 656-676. https://doi.org/10.1038/ajg.2013.79
Eke CB. Advances in gastrointestinal endoscopy: Shaping diagnosis and therapy of gastrointestinal disorders in children. Niger J Pediatr 2019;46(3):124-128.http://doi.org/10.4314/njp.v46i3.1
American Society for Gastrointestinal Endoscopy (ASGE) Standards of Practice Committee, Lightdale JR, Acosta R, et al. American Society for Gastrointestinal Endoscopy. Modifications in endoscopic practice for pediatric patients. Gastrointest Endosc 2014;79(5);699-710. https://doi.org/10.1016/j.gie.2013.08.014
Thakkar K, Lucia CJ, Ferry GD, McDuffie A, Watson KL. Repeat endoscopy affects patients management in paediatric inflammatory bowel disease. Am J Gastroenterol 2009;104(3):722-727. https://doi.org/10.1038/ajg.2008.111
Chang MT, Wang TH, Jsu JY, Lee TC, Wang CY, Yu JY. Endoscopic examination of the upper gastro-intestinal tract in infancy. Endosc 1983;29(1):15-17.
Suzuki H, Kato J, Kuriyama M, Hiraoka S, Kuwaki K, Yamamoto K. Specific endoscopic features of ulcerative colitis complicated by cytomegalovirus infection colitis. World J Gastroenterol 2010;16(10):1245-1251. https://doi.org/10.3748/wjg.v16.i10.1245
Cox CB, Laborda T, Kynes JM, Hiremath G. Evolution in the practice of pediatric endoscopy and sedation. Front Pediatr 2021;14(9):687635. https://doi.org/10.3389/fped.2021.687635
Thomson M, Tringali A, Dumonceau J-M, et al. Paediatric gastrointestinal endoscopy: European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) and European Society of Gastrointestinal Endoscopy Guidelines (ESGE). J Pediatr Gastroenteerol Nutr 2017;64(1):133-153. https://doi.org/10.1097/mpg.0000000000001408
Guariso G, Meneghel A, Pozza LVD, et al. Indications for gastrointestinal endoscopy in children with dyspepsia. J Pediatr Gastroenterol Nutr 2010;50(5):493-499. https://doi.org/10.1097/mpg.0b013e3181bb3362
Pall H, Lerner D, Khlevner J, et al. Developing the pediatric gastrointestinal endoscopy unit: A clinical report by the endoscopy and procedures committee. J Pediatr Gastroenterol Nutr 2016:63(2):295-306. https://doi.org/10.1097/mpg.0000000000001189
Kelly P, Katema M, Amadi B, et al. Gastrointestinal pathology in the University Teaching Hospital, Lusaka, Zambia: Review of endoscopic and pathology records. Trans Royal Soc Trop Med Hyg 2008;102(2):194-199. https://doi.org/10.1016/j.trstmh.2007.10.006
Adeniyi OF, Lesi OA, Odeghe FA, Adekola O, Oduwole O. Upper gastrointestinal endoscopy in children: The Lagos University Teaching Hospital experience. S Afr J Child Health 2016;10(4):207-201. https://doi.org/10.7196/SAJCH.2016.v10i4.1116
Mudawi HM, El Tahir MA, Suleiman SH, et al. Pediatric gastrointestinal endoscopy: Experience in a Sudanese university hospital. East Mediterr Health J 2009;15 (4):1027-1031. https://doi.org/10.26719/2009.15.4.1027
Lyons H, Zhang Y, Szpunar S, Dhamaraj R. Predictors of positive esophagogastroduodenoscopy outcomes in children and adolescents: A single centre experience. BMC Res Notes 2017;10(1):356. https://doi.org/10.1186/s13104-2693-7
Western Cape Department of Health. Western Cape Government Provincial Gazette Extraordinary 77752. Uniform patient fee schedule regulation for health services rendered by the Western Cape Department of Health. 31 March 2017.
Vazeou A, Papadopoulou A, Booth IW, Bartsocas CS. Prevalence of gastrointestinal symptoms in children and adolescents with type 1 diabetes. Diabetes Care 2001;24(5):962-964. https://doi.org/10.2337/diacare.24.5.962
Lei P, Gu F, Hong L, et al. Pediatric colonoscopy in South China: A 12-year experience in a tertiary centre. PLoS One 2014;9(4):e95933. https://doi.org/10.1371/journal.pone.0095933
Yoshioka S, Takedathus H, Fukunaga S, et al. Study to determine guidelines for pediatric colonoscopy. World J Gastroenterol 2017;23(31):5773-5779. https://doi.org/10.3748%2Fwjg.v23.i31.5773
Lee WS, Zainuddin H, Boey CCM, Chai PF. Appropriateness, endoscopic findings and contributive yield of pediatric gastrointestinal endoscopy. World J Gastroenterol 2013;19(47):9077-9083. https://doi.org/10.3748%2Fwjg.v19.i47.9077
Crowley E, Hussey S. Helicobacter pylori in childhood. In: Wyllie R, Hyams JS, Kay M (editors). Pediatric Gastrointestinal and Liver Disease. 5th edition. Philadelphia: Elsevier, 2016:309-327.
Thomson M, Sharma S. Diagnostic yield of upper and lower gastrointestinal endoscopies in children in a tertiary centre. J Pediatr Gastroenterol Nutr 2017;64(6):903-908. https://doi.org/10.1097/mpg.0000000000001582
Thakker K, Holub JL, Gilger MA, et al. Quality indicators for pediatric colonoscopy results from a multi-center consortium. Gastrointest Endosc
;83(3):533-541. https://doi.org/10.1016/j.gie.2015.06.028
Wu CT, Chen CA, Yang YJ. Characteristics and diagnostic yield of pediatric colonoscopy in Taiwan. Pediatr Neonatol 2015;56(5):234-238. https://doi.org/10.1016/j.pedneo.2015.01.005
Wu FY, Wu JF, Ni YH. Long-term outcome after percutaneous gastrostomy in children. Pediatr Neonatol 2013;54(5):326-329. https://doi.org/10.1016/j.pedneo.2013.04.008
Sharma R, Williams AN, Zaw W. Timing of gastrostomy insertion in children with a neuro-disability: A cross-sectional study of early versus late intervention. BMJ Open 2012;2:e001793. https://doi.org/10.1136/bmjopen-2012-001793
Itha S, Yachha SK. Endoscopic outcome beyond esophageal variceal eradication in children with extrahepatic portal vein obstruction. J Pediatr Gastroenterol Nutr 2006;42(2):196-200. https://doi.org/10.1097/01.mpg.0000189351.55666.45
Kerur B, Litman HJ, Stern JB, et al. Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. World J Gastroenterol 2017;23(18):3322-3329. https://doi.org/10.3748/wjg.v23.i18.3322
Hyams J, Markowitz J, Otley A, et al. Evaluation of the pediatric Crohn Disease Activity Index: A prospective multicenter experience. J Pediatr Gastroenterol 2005;41(4):416-421. https://doi.org/10.1097/01.mpg.0000183350.46795.42
Lin CH, Wu RSC, Lin WC, Wu SF, Chen AC. Colonoscopic polypectomy of colorectal polyps in children under general anaesthesia. Kovohsiung J Med Sci 2009;25(2):70-76. https://doi.org/10.1016/s1607-551x(09)70043-9
Eke CB, Brown RA, De Lacy RJ, Pillay K, Goddard EA. Collagenous gastritis: An unusual cause of generalised oedema in a child. J Tropical Pediatrics 2019;65(3):305-308. https://doi.org/10.1093/tropej/fmy048
Sheiko MA, Feinstein JA, Capocelli KE, Kramer RE. Diagnostic yield of oesophagogastroduodenoscopy in children: A retrospective single centre study of 10 000 cases. Gastrointest Endosc 2013:78(1):47-54. https://doi.org/10.1016%2Fj.gie.2013.03.168
O’Loughlin EV, Dutt S, Kamath R, Gaskin K, Domey S. Prospective peer-review audit of paediatric upper gastrointestinal endoscopy. J Paediatr Child Health 2007:43(7-8):551-554. https://doi.org/10.1111/j.1440-1754.2007.01132.x
Oliva S, Thomson M, de Ridder L, et al. Endoscopy in pediatric IBD: A position paper on behalf of the Porto IBD Group of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2018;67(3):414-430. https://doi.org/10.1097/mpg.0000000000002092
Lee WS, Tee CW, Koay ZL, et al. Quality indicators in pediatric colonoscopy in a low-volume center: Implications for training. World J Gastroenterol 2018;24(9):1013-1021. https://doi.org/10.3748/wjg.v24.i9.1013
Keane J, Gershon S, Wise RP, et al. Tuberculosis associated with infliximab, tumour necrosis factor alpha-neutralizing agent. N Engl J Med 2001;345(15):1098-1104. https://doi.org/10.1056/nejmoa011110
Abdool Karim SS, Churchyard GJ, Abdool Karim Q, Lawn SD. HIV infection and tuberculosis in South Africa: An urgent need to escalation the public health response. Lancet 2009;374(9693):921-933. https://doi.org/10.1016%2FS0140-6736(09)60916-8
Ammar MS, Pfefferkorn MD, Goffie JM, Gupta SK, Corkins MR, Fitzgerald JF. Complications after outpatient upper gastrointestinal endoscopy in children: 30-day follow-up. Am J Gastroenterol 2003;98(7):1508-1511. https://doi.org/10.1111/j.1572-0241.2003.07524.x