The integration of artificial intelligence into intravascular optical coherence tomography
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Keywords

Cardiovascular health
imaging
AI in healthcare

How to Cite

The integration of artificial intelligence into intravascular optical coherence tomography. (2026). Undergraduate Research in Health Journal, 4(1), e4150. https://doi.org/10.1796/

Abstract

Intravascular optical coherence tomography (IVOCT) is an imaging system that is used in interventional cardiology to diagnose coronary atherosclerosis. It is a tool that produces high-resolution images that are used to visualise the microstructure of the coronary arteries. However, while IVOCT produces clear and sharp images to be used in diagnoses, the data produced are complex and voluminous, requiring large amounts of time and human effort to interpret. Recently, IVOCT has seen vast improvements and important advances. The objective of this literature review is to provide a critical analysis of the integration of artificial intelligence (AI) into IVOCT imaging, explore the achievements made, highlight the challenges faced, and map out the future trajectory of this technology. To fulfil this objective, several scientific studies and peer-reviewed journal articles were critically reviewed to illuminate the recent advances in AI-driven IVOCT imaging. The review focuses on addressing image pre-processing, segmentation, stent detection, plaque characterisation, stent malapposition and neointimal coverage assessment. Special considerations have also been given to the practical applications of these systems in clinical situations, especially in the South African low-resource context. The integration of AI into IVOCT imaging has powerful potential to increase the efficiency of image analysis, diagnostic accuracy, clinical reasoning and decision-making processes, thus forging a new and optimistic path for the future of cardiovascular care and precision medicine.

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References

1. Centers for Disease Control and Prevention. Heart disease facts. 24 October 2024. https://www.cdc.gov/ heart-disease/data-research/facts-stats/index.html (accessed 20 August 2025).

2. Abdelatif N, Peer N, Manda SO. National prevalence of coronary heart disease and stroke in South Africa from 1990 - 2017: A systematic review and meta-analysis. Cardiovasc J Afr 2021;32(3):156-160. https://doi. org/10.5830/CVJA-2020-045

3. Himmett A. The diagnosis of coronary artery disease. Coronary Artery Disease Foundation, 2025. https:// coronaryarterydisease.org/the-diagnosis-of-coronary-artery-disease/ (accessed 20 August 2025).

4. Feldman MD, Cabe AG, Milner TE. IVOCT has a bright future in the identification of vulnerable plaques. JACC Cardiovasc Imaging 2019;12(8):1529-1531. https://doi.org/10.1016/j.jcmg.2018.10.008

5. Kromydas B. Understanding convolutional neural networks: A complete guide. LearnOpenCV, 18 January 2023. https://learnopencv.com/understanding-convolutional-neural-networks-cnn/ (accessed 15 August 2025). 6. Lin YT, Wang BC, Chung JY. Identifying acute aortic syndrome and thoracic aortic aneurysm from chest radiography in the emergency department using convolutional neural network models. Diagnostics

2024;14(15):1646. https://doi.org/10.3390/diagnostics14151646

7. Lee J, Prabhu D, Kolluru C, et al. Automated plaque characterization using deep learning on coronary

intravascular optical coherence tomographic images. Biomed Opt Express 2019;10(12):6497-6515. https://

doi.org/10.1364/BOE.10.006497

8. Liu P, Lu Z, Hou W, et al. Automated comprehensive evaluation of coronary artery plaque in IVOCT using deep learning. iScience 2025;28(4):112169. https://doi.org/10.1016/j.isci.2025.112169

9. Guo Y. Deep local global refinement network for stent analysis in IVOCT images. arXiv:1909.10169v1.

https://doi.org/10.48550/arXiv.1909.10169

10. Wu P, Gutiérrez-Chico JL, Tauzin H, et al. Automatic stent reconstruction in optical coherence tomography based on a deep convolutional model. Biomed Opt Express 2020;11(6):3374-3394. https://doi.org/10.1364/ BOE.390113

11. Yang G, Mehanna E, Li C, et al. Stent detection with very thick tissue coverage in intravascular OCT. Biomed Opt Express 2021;12(12):7500-7516. https://doi.org/10.1364/BOE.444336

12. Gharaibeh Y, Lee J, Zimin VN, et al. Prediction of stent under-expansion in calcified coronary arteries using machine learning on intravascular optical coherence tomography images. Sci Rep 2023;13(1):18110. https:// doi.org/10.1038/s41598-023-44610-9

13. Di Marcantonio G. Prediction of major adverse cardiovascular events using artificial intelligence and intracoronary optical coherence tomography. WebThesis, University of Turin, 2025. https://webthesis. biblio.polito.it/34873/ (accessed 17 August 2025).

14. Zhai Y, Shang H, Li Y, Zhang N, Zhang J, Wu S. A systematic review of risk factors for major adverse cardiovascular events in patients with coronary heart disease who underwent percutaneous coronary intervention. Front Physiol 2025;16:1514585. https://doi.org/10.3389/fphys.2025.1514585

15. Sharda S. SGPGI gets AI-enabled cardiac imaging technology for precision angioplasty. Times of India, 10 May 2025. https://timesofindia.indiatimes.com/city/lucknow/sgpgi-gets-ai-enabled-cardiac-imaging- technology-for-precision-angioplasty/articleshow/121040901.cms (accessed 20 August 2025).

16. Mitchell HR, Buccola J, Sibbald M, Pinilla-Echeverri N. Impact of artificial intelligence enhanced optical coherence tomography software on percutaneous coronary intervention decisions. OCT News, 15 January 2025. https://octnews.org/impact-of-artificial-intelligence-enhanced-optical-coherence-tomography-software- on-percutaneous-coronary-intervention-decisions/ (accessed 18 August 2025).

17. Chen X, Huang Y, Jessney B, et al. Review and recommendations for using artificial intelligence in intracoronary optical coherence tomography analysis. arXiv:2501.18614v1. https://doi.org/10.48550/ arXiv.2501.18614

18. Chu M, Jia H, Gutiérrez-Chico JL, et al. Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques. EuroIntervention 2021;17(1):41-50. https:// doi.org/10.4244/EIJ-D-20-01355

19. Schouten D, Nicoletti G, Dille B, et al. Navigating the landscape of multimodal AI in medicine: A scoping review on technical challenges and clinical applications. Med Image Anal 2025;105:103621. https://doi. org/10.1016/j.media.2025.103621

20. Gallen RA, O’Mahony JF, Kuntz KM, McGorrian C, Casserly IP, Blake GJ. Microcosting analysis of percutaneous coronary intervention with and without intracoronary imaging in an Irish tertiary referral centre. Open Heart 2025;12(1):e002988. https://doi.org/10.1136/openhrt-2024-002988

21. Gillwald A, Mothobi O, Rademan B. The state of ICT in South Africa. Research ICT Africa, 30 July 2018. https://researchictafrica.net/research/state-of-ict-in-south-africa/ (accessed 25 August 2025).

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