Depemokimab in eosinophilic asthma – a new era in biological therapy?

S Pillay

doi:10.7196/

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Published: 2025-03-28

DOI: https://doi.org/10.7196/

S Pillay

Pulmonology Fellow, Division of Pulmonology, Department of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

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AJTCCM Vol. 31 No. 1

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Breath-Taking News

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How to Cite

Pillay S. Depemokimab in eosinophilic asthma – a new era in biological therapy?. Afr J Thoracic Crit Care Med [Internet]. 2025 Mar. 28 [cited 2026 Apr. 17];31(1):e3332. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/3332

References

1. Jackson DJ, Wechsler ME, Jackson DJ, et al. Twice-yearly depemokimab in severe asthma with an eosinophilic phenotype. N Engl J Med 2024;391(24):2337-2349. https://doi.org/10.1056/NEJMoa2406673

2. Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial. Lancet 2012;380(9842):651-659. https://doi.org/10.1016/S0140-6736(12)60988-X

3. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353(5):487- 497. https://doi.org/10.1056/NEJMra050100

4. Crimi C, Calabrese C, D’Amato M, et al. Patient and physician perspectives on biological treatment in severe asthma: A Severe Asthma Network Italy survey. ERJ Open Res 2023;9(6):00560-2023. https://doi.org/10.1183/23120541.00560-2023

5. Lion-Cachet HC, Musonda JMM, Omole OB. Severe asthma in South Africa: A literature review and management approach for primary care. S Afr Fam Pract 2021;63(1):e1-e10. https://doi.org/10.4102/safp. v63i1.5179

6. GlobalInitiativeforAsthma.GlobalStrategyforAsthmaManagementandPrevention, 2024. www.ginasthma.org (accessed 19 February 2025).

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Editorial board

Editor-in-chief

Prof K Dheda, MB BCh (Wits), FCP(SA), FCCP, PhD (Lond), FRCP (Lond). Head Department the Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Professor of Mycobacteriology and Global Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Director, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, South Africa.

Deputy Editor

Prof C Koegelenberg, MB ChB, MMed (Int), FCP (SA), MRCP (UK), Cert Pulm (SA), PhD. Senior Specialist: Pulmonology & General Medicine, University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

Section Editor: Breath-taking News

Prof E M Irusen, MB ChB, FCP(SA), PhD. Head: Division of Pulmonology Department of Medicine Faculty of Health Sciences University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

President SA Thoracic Society

Prof. R Masekela, MB BCh, MMed (Paeds)Pret, Dipl Allerg (SA), PhD, FCCP. Adjunct Professor, Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, South Africa.
Expertise: Paediatrics, asthma, chronic lung disease, epidemiology

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