A WT1-positive pleural neoplasm. Is it always a mesothelioma? Diagnostic pitfall of WT1 immunohistochemistry in pleural neoplasm

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Published: 2023-09-19
Keywords:
serous carcinoma, peritoneum, WT1, PAX8, pleura

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G Gaggero
IRCCS Ospedale Policlinico San Martino, U.O. Anatomia patologica ospedaliera. Genova. Italy.
https://orcid.org/0000-0001-9098-563X
D Taietti
Pathology Unit, ASST del Garda, Desenzano del Garda, Brescia, Italy
https://orcid.org/0000-0002-7249-9109
M Concardi
Università di Genova, Scuola di Scienze Mediche e Farmaceutiche, Department of Integrated Surgical and Diagnostic Sciences (DISC), Division of Anatomic Pathology, Genoa, Italy
https://orcid.org/0000-0003-2715-4993
M Mora
IRCCS Ospedale Policlinico San Martino, U.O. Anatomia patologica ospedaliera, Genova, Italy

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AJTCCM Vol. 29 No. 3

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How to Cite

1.
Gaggero G, Taietti D, Concardi M, Mora M. A WT1-positive pleural neoplasm. Is it always a mesothelioma? : Diagnostic pitfall of WT1 immunohistochemistry in pleural neoplasm. Afr J Thoracic Crit Care Med [Internet]. 2023 Sep. 19 [cited 2025 Oct. 2];29(3):141. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/422

References

Husain AN, Colby TV, Ordóñez NG, et al. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017: Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch Pathol Lab Med 2018;142(1):89- 108. https://doi.org/10.5858/arpa.2017-0124-RA.

Anwar A, Kasi A. Peritoneal Cancer. 2022 Feb 24. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan.

Laury AR, Hornick JL, Perets R, et al. PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma. Am J Surg Pathol 2010;34(5):627-35. https:// doi.org/10.1097/PAS.0b013e3181da7687.

Attanoos RL, Webb R, Dojcinov SD, Gibbs AR. Value of mesothelial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary carcinoma of the ovary and peritoneum. Histopathology 2002;40(3):237- 244. https://doi.org/10.1046/j.1365-2559.2002.01352.x.