Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant

V Singh; R Perumal; M Wessels; F Hai; K Lutchminarain; K Naidoo; K Swe Swe-Han

doi:10.7196/AJTCCM.2025.v31i2.2346

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Published: 2025-06-04

DOI: https://doi.org/10.7196/AJTCCM.2025.v31i2.2346

Keywords:

Extensively Drug-Resistant Tuberculosis, Perinatal tuberculosis

V Singh

Department of Medical Microbiology, Albert Luthuli Laboratory, National Health Laboratory Service, Durban, South Africa; Department of Medical Microbiology, School of Laboratory Medicine and Medical Science, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

https://orcid.org/0009-0001-1292-760X

R Perumal

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa; South African Medical Research Council-Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Department of Pulmonology and Critical Care, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

https://orcid.org/0000-0001-8892-2904

M Wessels

Queen Nandi Regional Hospital, KwaZulu-Natal Provincial Department of Health, South Africa

https://orcid.org/0009-0004-8191-1486

F Hai

King Dinuzulu Hospital Complex, KwaZulu-Natal Provincial Department of Health, South Africa

https://orcid.org/0009-0002-5190-7780

K Lutchminarain

https://orcid.org/0000-0002-0839-3369

K Naidoo

https://orcid.org/0000-0002-8874-6661

K Swe Swe-Han

https://orcid.org/0000-0002-4574-6258

Abstract

We describe a rare case of perinatally acquired extensively drug-resistant tuberculosis in an infant. The infant was successfully treated with an individualised all-oral multidrug regimen containing delamanid, a drug rarely described in the treatment of perinatal tuberculosis.

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AJTCCM Vol. 31 No. 2

Section

Original Research: Brief Reports

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How to Cite

Singh V, Perumal R, Wessels M, Hai F, Lutchminarain K, Naidoo K, et al. Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant. Afr J Thoracic Crit Care Med [Internet]. 2025 Jun. 4 [cited 2025 Oct. 2];31(2):e2346. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/2346

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Prof K Dheda, MB BCh (Wits), FCP(SA), FCCP, PhD (Lond), FRCP (Lond). Head Department the Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Professor of Mycobacteriology and Global Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Director, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, South Africa.

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Prof. R Masekela, MB BCh, MMed (Paeds)Pret, Dipl Allerg (SA), PhD, FCCP. Adjunct Professor, Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, South Africa.
Expertise: Paediatrics, asthma, chronic lung disease, epidemiology

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