Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant
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Abstract
We describe a rare case of perinatally acquired extensively drug-resistant tuberculosis in an infant. The infant was successfully treated with an individualised all-oral multidrug regimen containing delamanid, a drug rarely described in the treatment of perinatal tuberculosis.
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References
1. World Health Organization. Global tuberculosis report 2023. Geneva: WHO, 2023.
https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-
reports/global-tuberculosis-report-2023 (accessed 10 June 2024).
2. World Health Organization. Meeting report of the WHO expert consultation on the definition of extensively drug-resistant tuberculosis. 27-29 October 2020. Geneva: WHO, 2020. https://www.who.int/publications/i/item/9789240018662 (accessed
10 June 2024).
3. Shenoi A, Kavitha A. Perinatal tuberculosis. Pediatr Infect Dis 2019;1(1):30-33.
https://doi.org/10.5005/jp-journals-10081-1107
4. Singh M, Kothur K, Dayal D, Kusuma S. Perinatal tuberculosis: A case series. J Trop Pediatr 2007;53(2):135-138. https://doi.org/10.1093/tropej/fml074
5. Cantwell MF, Shehab ZM, Costello AM, et al. Brief report: Congenital tuberculosis. N Engl J Med 1994;330(15):1051-1054. https://doi.org/10.1056/ NEJM199404143301505
6. WorldHealthOrganization.WHOconsolidatedguidelinesontuberculosis.Module5: Management of tuberculosis in children and adolescents. Geneva: WHO, 2022. https://www.who.int/publications/i/item/9789240046764 (accessed 12 June 2024).
7. National Department of Health, South Africa. Clinical management of rifampicin- resistant tuberculosis: Updated clinical reference guide. Pretoria: NDoH, 2023. https:// knowledgehub.health.gov.za/elibrary/clinical-management-rifampicin-resistant- tubercolosis (accessed 12 June 2024).
8. World Health Organization. WHO consolidated guidelines on tuberculosis. Module 1: Prevention – tuberculosis preventive treatment. Geneva: WHO, 2024. https://www. who.int/publications/i/item/9789240096196 (accessed 13 September 2024).
9. Boast A, How JA, Lau C, et al. Pre-extensively drug-resistant congenital tuberculosis in an extremely premature baby. Clin Infect Dis 2024;78(1):149-153. https://doi. org/10.1093/cid/ciad540
10. Espiritu N, Aguirre L, Jave O, Sanchez L, Kirwan DE, Gilman RH. Congenital transmission of multidrug-resistant tuberculosis. Am J Trop Med Hyg 2014;91(1):92-95. https://doi.org/10.4269/ajtmh.13-0002