First-line treatment of pulmonary sarcoidosis with prednisone or methotrexate

D J Lamprecht

doi:10.7196/

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Published: 2025-09-04

DOI: https://doi.org/10.7196/

Keywords:

first line treatment, methotrexate

D J Lamprecht

Pulmonology Fellow, University of the Witwatersrand and Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa

Abstract

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AJTCCM Vol. 31 No. 3

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Breath-Taking News

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How to Cite

Lamprecht DJ. First-line treatment of pulmonary sarcoidosis with prednisone or methotrexate. Afr J Thoracic Crit Care Med [Internet]. 2025 Sep. 4 [cited 2026 Apr. 19];31(3):e4189. Available from: https://samajournals.co.za/index.php/ajtccm/article/view/4189

References

1. Dhooria S, Singh Sehgal I, Agarwal R, et al. High-dose (40 mg) versus low-dose (20 mg) prednisolone for treating sarcoidosis: A randomised trial (SARCORT trial). Eur Respir J 2023;62(3):2300198. https://doi.org/10.1183/13993003.00198-2023

2. Kahlmann V, Janssen Bonás M, Moor CC, et al. First-line treatment of pulmonary sarcoidosis with prednisone or methotrexate. N Engl J Med 2025;393(3):231-242. https://doi.org/10.1056/NEJMoa2501443

3. ick SS, Lieberman ES, Rahman MU, Choi HK. Glucocorticoid use, other associated factors, and the risk of tuberculosis. Arthritis Rheum 2006;55(1):19-26. https://doi. org/10.1002/art.21705

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Editor-in-chief

Prof K Dheda, MB BCh (Wits), FCP(SA), FCCP, PhD (Lond), FRCP (Lond). Head Department the Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Professor of Mycobacteriology and Global Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Director, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, South Africa.

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Prof C Koegelenberg, MB ChB, MMed (Int), FCP (SA), MRCP (UK), Cert Pulm (SA), PhD. Senior Specialist: Pulmonology & General Medicine, University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

Section Editor: Breath-taking News

Prof E M Irusen, MB ChB, FCP(SA), PhD. Head: Division of Pulmonology Department of Medicine Faculty of Health Sciences University of Stellenbosch & Tygerberg Academic Hospital, South Africa.

President SA Thoracic Society

Prof. R Masekela, MB BCh, MMed (Paeds)Pret, Dipl Allerg (SA), PhD, FCCP. Adjunct Professor, Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, South Africa.
Expertise: Paediatrics, asthma, chronic lung disease, epidemiology

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